Dengke Ma, Professor

Closed (1) Genetic Analysis of C. elegans Extremophiles

Closed. This professor is continuing with Fall 2017 apprentices on this project; no new apprentices needed for Spring 2018.

Extremophiles refer to organisms that can survive or even thrive under extreme conditions, e.g. freezing or anoxia (0% oxygen) environments. C. elegans is a nematode model organism that can be deeply frozen and thawed alive (larvae), and can survive anoxia (larvae and adults) as well for prolonged periods of time. The underlying mechanisms remain unknown. Our research aims to identify C. elegans mutants with altered capabilities to survive under such extreme conditions. We will then analyze such mutants and genes defined by them. This will help understand fundamental mechanisms of how molecules and pathways mediate extremophile tolerance and bear potential relevance to a variety of medical problems (e.g. organ transplantation, ischemic stroke disorders etc).

Working with PI and a postdoctoral scholar, learning genetics, molecular biology, transgenic techniques and physiological studies. The student will also discuss with PI and other lab members to learn how to design effective and efficient experiments to address fundamental questions of biological problems.

Weekly Hours: more than 12 hrs

Off-Campus Research Site: 555 Mission Bay South Blvd, SCVRB Room 252X

Related website: http://malab.ucsf.edu
Related website: http://profiles.ucsf.edu/dengke.ma