Bone structure and composition: a microCT and microFTIR study
Galateia Kazakia, Professor
UC San Francisco, Electrical Engineering and Computer Science
Closed. This professor is continuing with Fall 2024 apprentices on this project; no new apprentices needed for Spring 2025.
Our research group focuses on advanced imaging techniques for the study of musculoskeletal structure and function (for details please see: http://www.radiology.ucsf.edu/research/kazakia). For this project, we plan to use two recently developed imaging tools to investigate the structure and composition of bone. State-of-the-art micro computed tomography (microCT) will be used to create three-dimensional high-resolution images of bone structure and density. Fourier transform infrared (FTIR) microspectroscopy will be used to investigate the composition of bone. Using these methods we will investigate bone quality in a number of diseases and animal models. This clinically relevant research will be performed in close collaboration with UCSF orthopaedic surgeons. A great opportunity for engineering or biology students to gain exposure to both laboratory and medical environments!
Role: Specific duties for the URAP student will include interfacing with surgeons for acquiring specimens, preparation of specimens from surgical and cadaver bones, microCT and FTIR imaging, and analysis of results. All training will be provided.
Qualifications: The student must be independently motivated and have extreme attention to detail and documentation.
The lab is situated in a new building on the UCSF Mission Bay campus. The campus is BART accessible –work schedule is flexible and can be adjusted to accommodate the commute from Berkeley. This is a great chance to learn about musculoskeletal issues in a clinically important project, while mastering advanced imaging techniques. Ideal for sophomores or juniors since a follow-up summer internship in the lab is possible, as well as continuation to the following school year.
Hours: 9-11 hrs
Off-Campus Research Site: UCSF Mission Bay Campus 1700 4th St San Francisco, CA
Related website: http://www.radiology.ucsf.edu/research/kazakia
Related website: https://bioegrad.berkeley.edu/people/galateia-kazakia