Molecular Epidemiology of Urinary Tract Infections
Eva Raphael, Professor
UC San Francisco
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Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, particularly among urban-dwelling women. UTIs are primarily caused by Escherichia coli (E. coli). UTIs may cause a range of complications from mild discomfort to severe kidney infections. As antibiotic resistance increases, treatment strategies for UTIs become ineffective. Our lab analyzes risk factors for UTIs among urban-dwelling women in the San Francisco Bay Area. Our group combines electronic history record data (e.g. age, race, ethnicity, medical history) with laboratory generated data (e.g. bacterial genotypes)to analyze risk factors for UTI and associated complications. Additionally, using molecular epidemiology methods (described below), we aim to characterize virulence factors and antibiotic resistance profiles which can inform targeted therapies and preventive measures.
Role: We are looking for a student ideally seeking long-term commitment experience in a wet lab. The student will gain hands-on experience with fundamental biological techniques, including PCR, DNA extraction, glycerol stocking, gel electrophoresis, and bacterial culturing. Initially, the student will shadow and assist with experiments, gradually progressing to conducting experiments independently. Participation in weekly meetings and presentations will be expected to discuss findings and share results. With further advancement, students will be able to conduct their own independent projects.
Qualifications: Students should have relevant biology coursework including Bio1A or equivalent (enrolled or previously taken). Lab experience is preferred, but not required.
Day-to-day supervisor for this project: Matthew Elises, Staff Researcher
Hours: 6-8 hrs
Off-Campus Research Site: Zuckerberg SF General
Biological & Health Sciences