Experimental identification of novel disease genes using functional genomics
Gabriel Loeb, Professor
Medicine, UCSF
Applications for Spring 2025 are closed for this project.
I am a scientist and physician with a broad interest in mechanisms underlying human disease. Our laboratory studies genetic mechanisms underlying kidney disease and develops approaches to discover novel disease mechanisms that are broadly applicable to many human diseases.
Many of the genetic variants (changes in the genome) which contribute to the development of human disease do not change protein coding sequence. Instead these genetic variants cause disease by regulating how and when genes are expressed. We use both experimental and computational approaches to identify the genes affected by disease causing genetic variants with the goal of enabling new therapies for human disease.
Qualifications: The student in this project will use functional genomics--specifically mutating or deleting regions of the genome using CRISPR tools--to identify novel kidney disease genes.
We are a young and growing laboratory, so the student will have significant opportunities to learn directly from the professor (who spends lots of time in the laboratory) and other trainees in the laboratory.
Research experience in a biology or chemistry laboratory is required.
Experience with cell culture is desired.
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Please include in the application
(1) Your career plan
(2) Schedule of committed hours to perform research in the lab (please exclude the commute time). The laboratory is at UCSF Mission Bay (555 Mission Bay Blvd S, San Francisco).
(3) Prior research/laboratory experience.
(4) (optional) experience that demonstrates attention to detail
Hours: to be negotiated
Off-Campus Research Site: UCSF Mission Bay Cardiovascular Research Institute 555 Mission Bay Blvd South San Francisco
Biological & Health Sciences