Comparative analysis of sensory neurons in common lab mice and spiny mice
Wendy Yue, Professor
UC San Francisco
Closed. This professor is continuing with Spring 2026 apprentices on this project; no new apprentices needed for Fall 2026.
Spiny mice are among the few mammals capable of shedding and regenerating large areas of skin, a unique adaptation that helps them escape predators. However, this ability comes with a challenge: how do they manage the pain from such severe injuries? This project investigates the excitability of pain-sensitive neurons in lab mice and spiny mice through calcium imaging. We will study the responses of dorsal root ganglion neurons (DRGs) to various agonists and skin wound exudate.
Role: Students will trace nerve structures in confocal images, dissect and dissociate DRGs, perform skin wounding surgeries, generate skin wound exudate and conduct calcium imaging experiments.
Qualifications: We seek students with an interest in neuroscience or biology in general, motivated to pursue laboratory research, and who work well in a collaborative setting. No prior experience is required, but attention to detail, curiosity, and a willingness to learn are essential.
Hours: to be negotiated
Off-Campus Research Site: Rock Hall Room 281 1550 4th Street UCSF Mission Bay Campus San Francisco, CA 94158
Related website: https://yuelab.ucsf.edu/
Biological & Health Sciences