URAP

Suzanne Fleiszig - Professor, Optometry

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: On Campus

Pseudomonas aeruginosa is the most common cause of contact lens-mediated microbial keratitis. Our lab uses in-vitro and in-vivo models to study the adaptation of Pseudomonas aeruginosa to the intracellular environment. Our recently published paper shows that intracellular bacteria persist in vacuoles, where they resist high-dose antibiotic...

Suzanne Fleiszig - Professor, Optometry

Status: Full- no new appr needed     Weekly Hours: 6-8 hrs     Location: On Campus

Pseudomonas aeruginosa is found to be the main causative agent of infection of human corneal and bronchial epithelial cells in bacterial keratitis and bacterial pneumonia respectively. To understand the etiology of chronic bacterial infection we look to determine the steps associated with intracellular biofilm formation by Pseudomonas aeruginosa. We aim...

Suzanne Fleiszig - Professor, Optometry

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: On Campus

Our lab has shown that P. aeruginosa can interact with and invade epithelial cells to establish an intracellular niche. We have recently found that intracellular bacteria occupy a subcellular compartment where they resist high dose antibiotic treatment. We are interested in understanding the factors associated with bacterial persistence and enhanced...

Suzanne Fleiszig - Professor, Optometry

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: On Campus

The cornea is endowed with a high density of sensory nerve endings, including some polymodal by virtue of their Transient Receptor Potential (TRP) cation channels. Recently, the Fleiszig lab reported that corneal nerves can modulate the healthy cornea’s susceptibility to bacterial adhesion involving TRPV1 and TRPA1. Our new data show...