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Eva Harris - Professor, Public Health; Div of Infectious Diseases and Vaccinology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
With 3.6 billion people living at risk of infection, and approximately 400 million infections and 96 million cases per year, dengue is the most prevalent mosquito-borne viral illness. The disease spectrum includes dengue fever, characterized by debilitating symptoms such as high fever and myalgia; and dengue hemorrhagic fever/dengue...
Biological & Health SciencesEva Harris - Professor, Public Health; Div of Infectious Diseases and Vaccinology
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
The four dengue virus serotypes (DENV1-4) cause the most important mosquito-borne viral disease of humans, with 100 million cases annually. The mechanisms by which the human immune response to DENV provides either protection against or enhancement of a subsequent infection with a different DENV serotype are not fully understood...
Biological & Health SciencesEva Harris - Professor, Public Health; Div of Infectious Diseases and Vaccinology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Previous studies in the Harris laboratory have demonstrated the ability of the secreted flaviviral protein, nonstructural protein 1 (NS1), to induce both hyperpermeability in vitro and vascular leak in vivo, both mediated by the disruption of endothelial glycocalyx components and intercellular junction degradation. Further work in the lab aims at...
Biological & Health SciencesEva Harris - Professor, Public Health; Div of Infectious Diseases and Vaccinology
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
Dengue (DENV) and Zika (ZIKV) flaviruses are mosquito-borne viruses that are major medical and public health problems worldwide. DENV causes the most prevalent mosquito-borne viral disease of humans, and severe cases manifesting vascular leakage can be fatal. Nonstructural protein 1 (NS1) is a flaviviral protein that participates in...
Biological & Health Sciences