URAP

Eva Nogales - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

Faithful development and maintenance of cell identity requires that the expression of specific genes is turned on and off in a highly regulated manner. This epigenetic regulation requires that chromatin-modifying complexes can be dynamically recruited across the genome and activated with high spatial and temporal control. Many of these...

Eva Nogales - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

The large transcription coactivators TFIID and SAGA play important roles in the regulation of gene expression. Over a megadalton in size, each of these complexes contains a number of structural modules with distinct functionalities. Interestingly, they share one particular module that plays different roles and that contains a number of...

Eva Nogales - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

DNA methylation at CpG sites plays an essential role in maintaining genome stability and regulating gene expression and it is strictly monitored and controlled by a series of molecular machines. Defects in DNA methylation are frequently found in severe diseases, such as cancer and Alzheimer's. DNMT1(DNA methyltransferase 1) with...

Eva Nogales - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Accurate segregation of chromosomes during cell division is essential for maintaining proper cellular function and organismal health. Errors in chromosome segregation can result in apoptosis or an abnormal chromosome number, leading to conditions such as Down syndrome and Turner syndrome, exposing detrimental recessive mutations, and being associated with cancer. The...