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Eva Nogales - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Faithful development and maintenance of cell identity requires that the expression of specific genes is turned on and off in a highly regulated manner. This epigenetic regulation requires that chromatin-modifying complexes can be dynamically recruited across the genome and activated with high spatial and temporal control. Many of these...
Biological & Health SciencesEva Nogales - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
The large transcription coactivators TFIID and SAGA play important roles in the regulation of gene expression. Over a megadalton in size, each of these complexes contains a number of structural modules with distinct functionalities. Interestingly, they share one particular module that plays different roles and that contains a number of...
Biological & Health SciencesEva Nogales - Professor, Molecular and Cell Biology
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
Kinesin motors drive microtubule based intracellular transport, and autoinhibition is an intrinsic regulatory mechanism that ensures this transport is activated according to cellular needs. Aberrant activation of kinesins has been linked to neurodegenerative diseases (e.g., KIF1A-Associated Neurological Disorder), affecting neuronal morphology and neurotransmitter release. However, the molecular mechanisms underlying...
Biological & Health SciencesEva Nogales - Professor, Molecular and Cell Biology
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
Glial cells (astrocytes, oligodendrocytes, and microglia), which make up half the brain volume, play essential roles in maintaining and protecting neurons. They regulate synaptic neurotransmission, insulate the neuronal axons, maintain their extracellular environment and are involved in immune defense, thereby playing a central role in the regulation of brain function...
Biological & Health Sciences