URAP

Lin He - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

Choroid plexus (ChP) epithelia contain multiple cilia per cells. Its major function is to secrete cerebrospinal fluid (CSF) to provide nutrients to the neurons and to cushion the brain from injury and inflammation. Defects in ChP lead to hydrocephalus, an abnormal buildup of fluid in the brain ventricles. Aberrant CSF...

Lin He - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Transposable elements (TEs) are DNA sequences capable of “moving” (transpose) within a genome. RNA transposons (retrotransposon) use RNA intermediate and a “copy and paste” mechanism to transpose. Retrotransposons, with their “copy and paste” mechanism, have accumulated and become abundant in our genome, comprising ~38% of the human and mouse genome...

Lin He - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

In mammals, female fertility is determined by the ovarian reserve of primordial follicles and the quality of mature MII oocytes. In humans, female fertility declines significantly after 35, with a rapid reduction in ovarian reserve and a severe deterioration in oocyte competence. On one hand, the pool of primordial follicles...

Lin He - Professor, Molecular and Cell Biology

Status: Check back for status     Weekly Hours: 12 or more hours     Location: On Campus

Throughout evolution, ancient foreign nucleic acid sequences have infected and spread across the genomes of nearly all organisms. Approximately 40% of the mammalian genome originates from mobile elements known as retrotransposons, which hijack the host's cellular machinery to replicate and integrate into the host genome via RNA intermediates. In most...