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Project Descriptions
Spring 2026

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Showing 4 projects out of 4 found. On page 1 out of 1.
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Adventures with the Coulter Principle

Max Staller - Assistant Researcher, Center for Computational Biology

Status: Current Term Now Closed     Weekly Hours: 6-8 hrs     Location: On Campus

Coulter Counters are very accurate machines for measuring cell number and volume...

 Biological & Health Sciences

Probing the evolution of transcription factor activation domains

Max Staller - Assistant Researcher, Center for Computational Biology

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: On Campus

Transcription factors contain DNA binding domains and separate activation domains that bind coactivator complexes. DNA binding domains are conserved, structured and can be predicted from amino acid sequence. Activation domains are intrinsically disordered (they do not fold into a single 3D structure), poorly conserved and cannot be predicted from amino...

 Biological & Health Sciences

Computational approaches to studying patient mutations in transcriptional activation domains

Max Staller - Assistant Researcher, Center for Computational Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

Our group has developed simple and highly predictive models for transcriptional activation domains. The goal of the project is to identify human activation domains enriched for patient mutations...

 Biological & Health Sciences

Computational studies of transcriptional activation domains

Max Staller - Assistant Researcher, Center for Computational Biology

Status: Current Term Now Closed     Weekly Hours: 9-11 hrs     Location: On Campus

Transcription factors contain DNA binding domains and separate activation domains that bind coactivator complexes. DNA binding domains are conserved, structured and can be predicted from amino acid sequence. Activation domains are intrinsically disordered (they do not fold into a single 3D structure), poorly conserved and cannot be predicted from amino...

 Biological & Health Sciences

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