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Max Staller - Assistant Researcher, Center for Computational Biology
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
It is now clear that roughly a third of the amino acids in human proteins are intrinsically disordered and do not fold into a single 3D structure. Some of these regions transiently fold when bound to partners, but many simply wiggle between many confirmations. These disordered regions cannot be visualized...
Biological & Health SciencesMax Staller - Assistant Researcher, Center for Computational Biology
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Transcription factors contain DNA binding domains and separate activation domains that bind coactivator complexes. DNA binding domains are conserved, structured and can be predicted from amino acid sequence. Activation domains are intrinsically disordered (they do not fold into a single 3D structure), poorly conserved and cannot be predicted from amino...
Biological & Health SciencesMax Staller - Assistant Researcher, Center for Computational Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Our group has developed simple and highly predictive models for transcriptional activation domains. The goal of the project is to identify human activation domains enriched for patient mutations...
Biological & Health Sciences