URAP

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

During development, cells self-organize to form functioning tissues, organs, and entire organisms. This requires tightly regulated communication between cells and their environment, to ensure correct signal uptake, integration, and response. Clathrin-mediated endocytosis (CME) is a major pathway by which cells take up extracellular cues and thus communicate with...

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: On Campus

Cells integrate extracellular cues (biochemical or mechanical signals) in order to direct specific cellular and tissue wide responses. The correct functioning of organs depends on this communication between cells and their surrounding environment. However, our understanding of how external mechanical inputs, such as increased pressure, direct cell function in health...

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

Auditory and vestibular senses are classic and essential senses of the body. The inner ear’s development, or morphogenesis, is a complex and well-regulated process that is guided by cell communication or signaling pathways. When signaling pathways become dysregulated, it often leads to deformities and/or diseases. And in the...

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Most life processes involve cells managing fluids. Our sense of hearing and balance depend on the tight regulation of inner ear fluid (endolymph) volume and pressure. Increased endolymph volume and pressure can lead to the development of deafness and balance disorders. Our previous work in zebrafish embryos has shown that...