URAP

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Compartmentalized fluid pressures organize many aspects of development and physiology. Because water is incompressible, pressure changes propagate rapidly and uniformly (Pascal’s law), coordinating collective cell behaviors. In the eye, fluid pressure plays an important role in producing and maintaining shape for vision. The anterior chamber (AC) of the eye is...

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Mechanical stress is a fact of life. Fluid pressure is required for the function of the circulatory system, ear, and eye. Tissues stretch and contract during morphogenesis, locomotion, and wound healing. But how do tissues (and the cells that constitute them) adapt and respond to changes in the physical stresses...

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

The vertebrate inner ear is composed of a series of connected fluid-filled cavities tightly regulated by undefined pressure-responsive mechanisms. Misregulation of this internal hydrostatic (fluid) pressure can result in developmental defects in the ear, hearing loss, and difficulties with balance. The endolymphatic sac (EDS) is a flexible chamber...

Ian Swinburne - Professor, Molecular and Cell Biology

Status: Check back for status     Weekly Hours: 12 or more hours     Location: On Campus

Most life processes involve cells managing fluids. Our sense of hearing and balance depend on the tight regulation of inner ear fluid (endolymph) volume and pressure. Increased endolymph volume and pressure can lead to the development of deafness and balance disorders. Our previous work in zebrafish embryos has shown that...