URAP

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

The Liver Receptor Homolog-1 (LRH-1) is an orphaned nuclear receptor (a family of protein transcription factors that regulate gene expression in the cell). Nuclear receptors contain a physical pocket known as the ligand binding domain (LBD) that is capable of binding and sensing various compounds. LRH-1&#039...

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Peroxisome proliferator-activated receptors (PPARs) form a subset of nuclear receptors, currently comprising three distinct members: PPARα, PPARγ, and PPARδ. Each receptor seems to influence pathways situated at the crossroads of intermediary metabolism and inflammation, imparting significant physiological and clinical relevance to them (Bensinger and Tontonoz, 2008). PPARα, a well...

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Inflammatory bowel disease (IBD) is an autoimmune inflammatory condition of the gastrointestinal tract. Statistics show that the incidence of IBD in the US is around 1.3% in the adult population. The pathophysiology of IBD is multifaceted and complex, with current therapeutics requiring optimization. Genome Wide Association Studies (GWAS) and experimental...

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Bile acids (BA), the amphipathic and water-soluble end-products of cholesterol metabolism, are essential for the emulsification and subsequent absorption of dietary lipids and fat-soluble vitamins. BA are synthesized by the liver, stored in the gallbladder, and secreted into the lumen of the small intestine to solubilize lipids...