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Carlotta Ronda - Principal Investigator, Innovative Genomics Institute
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Discovering molecular binders that recognize specific receptors is central to applications in diagnostics, biosensing, and microbiome engineering. Bacterial surface display offers a compact and accessible system to present candidate binders (e.g., nanobodies) on E. coli and test their ability to interact with target receptors. This project will use E. coli...
Carlotta Ronda - Principal Investigator, Innovative Genomics Institute
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Gram-positive microbes are important members of host-associated and environmental microbiomes, yet many remain genetically intractable. This project will implement novel microbiome editing tools by developing modular plasmids that can either replicate or integrate into the genomes of these difficult-to-engineer bacteria, and by establishing workflows for introducing...
Carlotta Ronda - Principal Investigator, Innovative Genomics Institute
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: On Campus
Inflammatory Bowel Disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a chronic gastrointestinal disorder driven by complex interactions between the host, microbiome, and immune system, with disruptions in this network contributing to disease onset and progression. Environmental and microbial factors can activate pathways that regulate intestinal homeostasis and...