URAP

Meng C. Lin - Professor, Optometry

Status: Current Term Now Closed     Weekly Hours: 9-11 hrs     Location: On Campus

This research investigates the fascinating impact of aging on the morphology of the Meibomian gland (MG), which plays a pivotal role in Ocular Surface Disease. Traditionally, clinicians have employed subjective methods to identify and grade MG features such as atrophy, tortuosity, length, width, and ghosting. At the exciting crossroads of...

Meng C. Lin - Professor, Optometry

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: On Campus

Scleral lenses, unlike standard contact lenses, are large-diameter rigid lenses that rest on the sclera (white part of the eye) and create a tear-filled reservoir to hydrate the anterior ocular surface. They are primarily recommended for patients with corneal irregularities and dry eye diseases due to their capability...

Fenyong Liu - Professor, Public Health

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

The long-term goals of our research are (1) to study the functions of genes of human herpes simplex virus (HSV) (the causative agent of genital herpes and cold sores) and cytomegalovirus (CMV) (the leading cause of congenital abnormalities in newborns and blindness and death in AIDS patients) in regulation...

Juan Liu - Professor, Integrative Biology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

Lateral line sensory system, or lateral line organ, or simply the lateral line, is a system of sensory organs found in fish and some tetrapods (four-legged vertebrates). The lateral line enables those vertebrates to detect and perceive the hydrodynamic and physical environment they inhabit including movement, vibration, and pressure...

Juan Liu - Professor, Integrative Biology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Scientific illustration is art in the service of science by drawing, painting, or rendering images of scientific subjects to accurately inform and communicate sciences. Research in fossil fishes (paleoichthyology) is at the junction of paleontology and ichthyology, and therefore, possesses characteristics of both —-- the incomplete nature of fossil preservations and...

Juan Liu - Professor, Integrative Biology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

Our study aims to explore the intricate details of mammalian hearing, with a specific emphasis on the function and evolution of the middle ear, with comparative anatomy with fish hearing apparatus. This critical aspect of auditory anatomy plays a pivotal role in the way mammals perceive and interpret sound. By...

Juan Liu - Professor, Integrative Biology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

Catfishes (Siluriformes) are remarkable among hearing specialist fishes in their possession of the Weberian apparatus, a conductive multi-ossicle chain linking the inner ear and swim bladder that is analogous to the middle ear ossicles of the mammalian tetrapods. Work with laboratory animals has produced considerable insight into the role...

John Liu - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

Glioblastoma (GBM) is the most common primary brain cancer. Despite decades of research to better treat this cancer, most patients unfortunately die within 2 years of diagnosis. Surgery followed by radiation therapy and chemotherapy comprise the standard of care for patients with GBM, but resistant to treatment poses a major...

Gabriel Loeb - Professor, Medicine, UCSF

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: Off Campus

I am a scientist and physician investigating molecular mechanisms underlying human disease--with a particular focus on kidney disease. My laboratory integrates computational approaches with human genetics and advanced experimental models to discover genetic mechanisms of disease. We have a particular interest in understanding the molecular basis of kidney disease...

Gabriel Loeb - Professor, Medicine, UCSF

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: Off Campus

I am a scientist and physician with a broad interest in mechanisms underlying human disease. Our laboratory studies genetic mechanisms underlying kidney disease and develops approaches to discover novel disease mechanisms that are broadly applicable to many human diseases. Many of the genetic variants (changes in the genome) which contribute...

Gabriel Loeb - Professor, Medicine, UCSF

Status: Full- no new appr needed     Weekly Hours: to be negotiated     

Polycystic Kidney Disease is the most common genetic cause of kidney failure. We know the genes that are mutated in Polycystic Kidney Disease but still do not have good treatments for patients with this disease. Our laboratory, which is led by a physician-scientist works on mechanisms underlying polycystic kidney...

Cynthia Looy - Professor, Integrative Biology

Status: Current Term Now Closed     Weekly Hours: 3-5 hrs     Location: On Campus

Pollinators are essential components of a healthy ecosystem and provide vital benefits to both plants and animals. The student-run pollinator garden on the south side of the Valley Life Science Building (VLSB) supports native insects, spiders, and other wildlife and is an environmental education resource for students. Our goal...

Cynthia Looy - Professor, Integrative Biology

Status: Full- no new appr needed     Weekly Hours: 6-8 hrs     Location: On Campus

Plants are adapted to the physical conditions in their environments, including temperature, precipitation, atmospheric CO2 concentrations, and light level. In cooler and drier habitats, leaves tend to be smaller with condensed venation and toothed margins. While under warmer and wetter conditions, leaves tend to be larger, have ‘drip tips’, and...

Dengke Ma - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Life requires a constant supply of energy, yet animals can adapt by slowing down or temporarily shutting off costly processes. One key strategy is ribosomal hibernation, in which ribosomes—the cell’s protein-making machines—pause activity to conserve resources. In the nematode C. elegans, ribosomal hibernation is linked to sleep...

Dengke Ma - Professor, UC San Francisco

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: Off Campus

The nematode C. elegans can be frozen alive, suspend life and revive later virtually any long after freezing, unlike many other multicellular organisms, including flies, fish, mice and humans. How C. elegans achieves this feat remains a fascinating unsolved mystery. This project will use our newly established reporters and assays...

Dengke Ma - Professor, UC San Francisco

Status: Check back for status     

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Megan Martik - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

The huge diversity of animal lifeforms that occupy virtually every ecological niche on our planet are all produced through the transformation of a single-celled zygote to a multicellular, fully functional organism via the processes encompassed by embryogenesis. It is through tweaks and changes to these developmental mechanisms that new...

Megan Martik - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

The evolution of vertebrates is intimately linked to the advent of the neural crest, a migratory and multipotent cell population that gives rise to many defining vertebrate characteristics, such as the jaw and peripheral gangilia. Where the neural crest arise along the body axis during developmement has great impacts on...

Megan Martik - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

The neural crest (NC) is a transient stem cell population that emerges during early vertebrate embryogenesis. Characterized by its migratory behavior and multipotency, the NC gives rise to diverse cell types and tissue derivatives including elements of the peripheral nervous system, the craniofacial skeleton, and the cardiovascular system. The NC...

Megan Martik - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

Neural crest is an embryonic stem cell population that originates in the neural tube and migrates into the developing organs such as the heart and gut to form diverse cell types, including neurons and muscle cells. BMP signaling plays an important role in their terminal differentiation, yet how BMP target...

Norma Cecilia Martinez Gomez - Professor, Plant and Microbial Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Methylotrophs are plant-associated bacteria that metabolize plant-derived methanol using lanthanide- or calcium-dependent methanol dehydrogenases. As interacting systems, methylotrophic communities form dynamic and metabolically diverse biofilms that contribute to the health of plants. However, the molecular mechanisms driving interactions between co-occurring methylotrophic symbionts remain poorly understood. As...

Jimmy McGuire - Professor, Museum of Vertebrate Zoology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

The island of Sulawesi in Indonesia is a hotspot of biodiversity and model system for studying the evolution of organisms. Our lab has conducted numerous expeditions to the island to document its biodiversity and collect samples for genetic analysis. Our lab uses molecular and morphological tools to reconstruct the evolutionary...

Jimmy McGuire - Professor, Museum of Vertebrate Zoology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Amphibians are the world’s most imperiled vertebrate group. Confounding efforts to combat amphibian declines is that we have little knowledge concerning most of the species and much of it not easily accessible. Since 2000, we have been developing an informatics platform to create a web page for every species of...

Marisa Medina - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

There are a limited number of human omics datasets that include menopausal status information for female subjects and include enough premenopausal and postmenopausal women. For instance, multi-omics data has been generated for thousands of Framingham Heart Study (FHS) participants and hundreds of TwinsUK female twin pairs. We will compare...

Marisa Medina - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

A subset of women experience an accelerated rise in certain cardiometabolic risk factors around the time of menopause, increasing their risk for heart disease and other conditions. We would like to discover why some women experience dramatic changes while others are relatively protected...

Patina Mendez - Lecturer, Environmental Science, Policy and Management

Status: Current Term Now Closed     Weekly Hours: 3-5 hrs     Location: On Campus

Streams in California have a variety of forms including: (a) intermittent streams that only flow for part of the year, and often are dry throughout the summer, (b) protected streams in national, state, regional, and county parts, and (c) urban streams that serve recreational needs and stormwater management. The project...

Patina Mendez - Lecturer, Environmental Science, Policy and Management

Status: Current Term Now Closed     Weekly Hours: 3-5 hrs     Location: On Campus

Studies in ecology and evolution rely on properly curated museum material and access to museum records and specimen. Caddisflies, in the insect order Trichoptera, are aquatic insects closely related to moths and butterflies. In this project, the student will assist with labeling, organizing, and curating caddisflies. The student will also...

Guanghan Meng - Professor, Optometry

Status: Current Term Now Closed     Weekly Hours: 9-11 hrs     Location: On Campus

Myopia (nearsightedness) is the most prevalent eye condition worldwide, affecting a rapidly growing portion of the population and requiring regular monitoring of eye health in both children and adults. Optical Coherence Tomography (OCT) is a widely adopted imaging technology for diagnosing ocular diseases and monitoring eye health. However, the high...

Craig Miller - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

A fantastic diversity in organismal form is seen in nature, yet we know little about the genetic basis of evolutionary change. We are using the head skeleton of the threespine stickleback (Gasterosteus aculeatus) as a model system to study the genetic basis of development and evolution. Sticklebacks have undergone one...

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

The Liver Receptor Homolog-1 (LRH-1) is an orphaned nuclear receptor (a family of protein transcription factors that regulate gene expression in the cell). Nuclear receptors contain a physical pocket known as the ligand binding domain (LBD) that is capable of binding and sensing various compounds. LRH-1&#039...

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

Peroxisome proliferator-activated receptors (PPARs) form a subset of nuclear receptors, currently comprising three distinct members: PPARα, PPARγ, and PPARδ. Each receptor seems to influence pathways situated at the crossroads of intermediary metabolism and inflammation, imparting significant physiological and clinical relevance to them (Bensinger and Tontonoz, 2008). PPARα, a well...

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

Inflammatory bowel disease (IBD) is an autoimmune inflammatory condition of the gastrointestinal tract. Statistics show that the incidence of IBD in the US is around 1.3% in the adult population. The pathophysiology of IBD is multifaceted and complex, with current therapeutics requiring optimization. Genome Wide Association Studies (GWAS) and experimental...

David Moore - Professor, Nutritional Sciences and Toxicology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Bile acids (BA), the amphipathic and water-soluble end-products of cholesterol metabolism, are essential for the emulsification and subsequent absorption of dietary lipids and fat-soluble vitamins. BA are synthesized by the liver, stored in the gallbladder, and secreted into the lumen of the small intestine to solubilize lipids...

Julian Motzkin - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

When pain becomes chronic, there can be changes in brain areas involved with processing pain signals. Our research combines fMRI of pain circuits with repetitive transcranial magnetic stimulation (rTMS), a type of non-invasive brain stimulation, to determine how rTMS may alleviate difficult-to-treat pain...

Mahasin Mujahid - Professor, Public Health

Status: Current Term Now Closed     Weekly Hours: 6-8 hrs     Location: On Campus

Cardiovascular diseases (CVD) are a major public health concern. Despite overall declines in cardiovascular disease (CVD) mortality over the past several decades, CVD remains the leading cause of death in the U.S., and significant health disparities remain, especially in rural communities. For example, rural populations experience higher rates of cardiovascular...

Praveen Mummaneni - Professor, Neurosurgery-Spine

Status: Current Term Now Closed     Weekly Hours: 9-11 hrs     Location: Off Campus

UCSF is a leading center for the American Spine Registry, a nationwide initiative focused on collecting patient data to enhance care for individuals undergoing cervical and lumbar surgeries. Our research team investigates the outcomes of minimally invasive surgeries, factors influencing cancer recurrence and complications in spinal tumors, and the effectiveness...

Michael Nachman - Professor, Museum of Vertebrate Zoology, Integrative Biology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

Within ~500 years, house mice (Mus musculus domesticus) have expanded into a wide variety of habitats across North and South America. House mice can be found from the tropics to the arctic, and populations inhabiting these different environments have adapted to different thermal regimes. This project will focus on the...

Michael Nachman - Professor, Museum of Vertebrate Zoology, Integrative Biology

Status: Full- no new appr needed     Weekly Hours: to be negotiated     Location: On Campus

Within ~500 years, house mice (Mus musculus domesticus) have expanded into a wide variety of habitats across North and South America. House mice can be found from the tropics to the arctic, and populations inhabiting these different environments have adapted to different thermal regimes. Mice from cold regions are larger...

Michael Nachman - Professor, Museum of Vertebrate Zoology, Integrative Biology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

A fundamental challenge in evolutionary biology is to understand how new species arise. The California vole is a widespread Californian rodent that appears generally uniform and is currently classified as a single species. However, recent studies have shown that the California vole forms two genetically distinct groups with reproductive isolation...

Eva Nogales - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

Faithful development and maintenance of cell identity requires that the expression of specific genes is turned on and off in a highly regulated manner. This epigenetic regulation requires that chromatin-modifying complexes can be dynamically recruited across the genome and activated with high spatial and temporal control. Many of these...

Eva Nogales - Professor, Molecular and Cell Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

The large transcription coactivators TFIID and SAGA play important roles in the regulation of gene expression. Over a megadalton in size, each of these complexes contains a number of structural modules with distinct functionalities. Interestingly, they share one particular module that plays different roles and that contains a number of...

Eva Nogales - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Kinesin motors drive microtubule based intracellular transport, and autoinhibition is an intrinsic regulatory mechanism that ensures this transport is activated according to cellular needs. Aberrant activation of kinesins has been linked to neurodegenerative diseases (e.g., KIF1A-Associated Neurological Disorder), affecting neuronal morphology and neurotransmitter release. However, the molecular mechanisms underlying...

Eva Nogales - Professor, Molecular and Cell Biology

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: On Campus

Glial cells (astrocytes, oligodendrocytes, and microglia), which make up half the brain volume, play essential roles in maintaining and protecting neurons. They regulate synaptic neurotransmission, insulate the neuronal axons, maintain their extracellular environment and are involved in immune defense, thereby playing a central role in the regulation of brain function...

Peter Oboyski - Sr. Museum Scientist, Essig Museum of Entomology

Status: Current Term Now Closed     Weekly Hours: 6-8 hrs     Location: On Campus

UCB campus: Bees are responsible for pollination of many food crops and native plants. Moth larvae (caterpillars) are important herbivores of native and domesticated plants. Both bees and moths, therefore, are important indicators of ecosystem health. We are currently working to take high resolution photographs of of the hundreds of...

Peter Oboyski - Sr. Museum Scientist, Essig Museum of Entomology

Status: Current Term Now Closed     Weekly Hours: 6-8 hrs     Location: On Campus

The Essig Museum is part of a large-scale collecting effort on the island of Sulawesi in Indonesia. We anticipate collecting vast quantities of bizarre and fascinating arthropods, many of which will be new to science. The two main goals of the project are to document the biological diversity of...

Peter Oboyski - Sr. Museum Scientist, Essig Museum of Entomology

Status: Full- no new appr needed     Weekly Hours: 6-8 hrs     Location: On Campus

The Essig Museum is actively collecting insect specimens across the state to document the diversity and conservation status of California's native and non-native species. Samples are captured using various complementary trapping techniques to maximize the number of species. Some of these specimens will be added to our DNA sequencing...

Peter Oboyski - Sr. Museum Scientist, Essig Museum of Entomology

Status: Current Term Now Closed     Weekly Hours: 6-8 hrs     Location: On Campus

Natural History Museums are repositories for biodiversity research, documentation of the impacts of global change, and a resource for new and innovative science. Managing these collections requires expertise in many disparate disciplines such as library science, anatomy & morphology, taxonomy, and data management. The Essig Museum houses over 5 million specimens...

Yuko Oda - Research Staff, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 6-8 hrs     Location: Off Campus

The goal of our research is to identify a mechanism how somatic stem cells determine their cell fate through stage or cell specific transcriptional and epigenetic program. We hypothesized that the vitamin D receptor and its regulator of Mediator is critical for temporal or spatial specific transcription to control epithelial...

Daniel Okamoto - Professor, Integrative Biology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Climate change is dramatically altering the oceans. These changes include increases in sea surface temperature, pH, dissolved oxygen, and primary productivity. We use experiments and field data to assess how these changes affect the physiology, growth, reproduction, and behavior of marine animals. We have numerous samples from past experiments and...

Daniel Okamoto - Professor, Integrative Biology

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: On Campus

Wild fish populations are often subject to high levels of mortality from industrialized human harvest. Harvest mortality, particularly under certain environmental contexts, may have indirect, unpredictable effects on populations' biology beyond simply the removal of individuals from a population. To study these effects, we are using an experimental model system...