Jean Nakamura

Closed (1) Investigating bioenergetics and targeting metabolic vulnerabilities in cancer

Applications for fall 2021 are now closed for this project.

Intrinsic cellular metabolic abnormalities emerge early in tumor development and persist throughout the disease course. Cellular growth signals are intimately connected to metabolism, and in malignant cells these connections are co-opted through both oncogene and tumor suppressor proteins. Using novel genetic and imaging approaches integrated with pre-clinical models, this project will investigate metabolism-based approaches to modulating cancer progression and therapy.

This project will involve developing skills in biochemical analysis of metabolic function in human cancer cells, statistical analysis, and education in bioenergetics of cancer development.

Day-to-day supervisor for this project: Danny Laurent, Post-Doc

Qualifications: Excellent documentation, coursework in biochemistry and physiology is highly helpful

Weekly Hours: 9-11 hrs

Off-Campus Research Site: UCSF Helen Diller Family Cancer Research Building at the Mission Bay campus

Related website: http://nakamuralab.ucsf.edu/

Closed (2) Genetic mechanisms of radiation-induced carcinogenesis

Applications for fall 2021 are now closed for this project.

Ionizing radiation (IR) is a mutagen that is naturally present in Earth’s environment, however, in space, IR exposures substantially exceed background levels on Earth. This increased exposure raises the concern that human space activity, particularly outside the earth’s magnetosphere, will result in negative health consequences related to IR. Radiation carcinogenesis is a particular concern but is poorly understood. Our laboratory developed murine models of IR-induced cancer that simulate cancer distributions and genetics to IR-induced neoplasms in humans. This project will focus on analyzing genetic sequences from these models to delineate genetic signatures of carcinogenesis and potential biomarkers. This work has direct relevance to NASA's planned manned missions and all human activities in deep space, and if highly productive, the undergraduate researcher could have opportunity for interaction with NASA researchers.

Day-to-day supervisor for this project: Danny Laurent, Post-Doc

Qualifications: This project will involve work with DNA, RNA, PCR, data organization, and statistical analysis. Individuals with prior coursework in areas of genetics, molecular biology, biochemistry and statistics will be preferred.

Weekly Hours: 9-11 hrs

Off-Campus Research Site: UCSF Mission Bay Campus

Related website: http://nakamuralab.ucsf.edu