Project 2: Extreme physiology (a) with low heart rates or (b) between identical twins (students with healthy low heart rates or identical twin brother/sister are particularly encouraged to apply)
Guo Huang, Professor
UC San Francisco
Closed. This professor is continuing with Fall 2023 apprentices on this project; no new apprentices needed for Spring 2024.
We aim to study whether there are extreme physiological phenomena (1) in individuals with healthy low heart rates (less than 45 beats/min) and (2) among identical twins that can not be explained by any known biological mechanism.
We will exploit classical and non-classical model systems to explore these uncharted areas. If you (1) have low heart rates but are healthy, or (2) have identical twin brother/sister, your prior personal experiences would be a very valuable asset to this project.
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Publications from previous URAP students [name]:
1. Hirose, K.*, Payumo, A. Y.*, Cutie, S., [Hoang, A.], et al., and Huang, G. N. (*, equal contribution) (2019 Apr) Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. Science
2. Cutie, S., [Hoang, A. T.], Payumo, A. Y., and Huang, G. N. (2017 Dec) Unconventional functions of muscles in planarian regeneration. Developmental Cell
3. Hirose, K., [Chang, S.], et al., and Huang, G. N. (Submitted) Loss of a novel striated muscle-enriched mitochondrial protein Coq10a enhances postnatal cardiac hypertrophic growth.
4. [Amram, A.], Cutie, S., and Huang, G. N. (2021 Jan) Hormonal control of cardiac regenerative potential. Endocrine Connections
5. [Khyeam, S.], [Lee, S.], and Huang, G. N. (2021 May) Genetic, epigenetic, and postâtranscriptional basis of divergent tissue regenerative capacities among vertebrates. Advanced Genetics, e10042
6. Payumo, A. Y.*, Chen, X.*, Hirose, K., Chen, X., Hoang, A., [Khyeam, S.], Yu, H., Wang, J., Chen, Q., [Powers, N.], Chen, L., Bigley, R. B., Lovas, J., Hu, G., and Huang, G. N. (*, equal contribution) (2021 Sep) Adrenergic-thyroid hormone interactions drive postnatal thermogenesis and loss of mammalian heart regenerative capacity. Circulation
7. [Amram AV], Cutie S, Huang GN. (2021 Jan) Hormonal control of cardiac regenerative potential. Endocr Connect.
8. [Khyeam S], [Lee S], Huang GN. (2021 Jun) Genetic, Epigenetic, and Post-Transcriptional Basis of Divergent Tissue Regenerative Capacities Among Vertebrates. Adv Genetics.
9. [Powers N], Huang GN. (2022 May) Mending a broken heart with novel cardiogenic small molecules. Cell Regeneration
10. [Powers N], Huang GN. (2022 May) Visualization of regenerating and repairing hearts. Clin Sci.
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Please include in the application
(1) your career plan,
(2) daily schedule of committed hours to perform research in the lab (please exclude the commute time),
(3) prior research experience if any,
(4) a link to your LinkedIn profile (with your head photo),
(5) a. whether you have healthy low heart rates, or b. whether you have an identical twin brother or sister,
(6)(optional) a one-sentence description if you are from diverse backgrounds in but not limited to ethnicity, sexual orientation, and geography (including international students with F1 visa).
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Role: Candidates will work with postdoctoral fellows and staff researchers in the lab. Students will also have the opportunity to engage directly with the professor.
Potential techniques and experience acquired during the training include:
- Advanced imaging microscopy on live or fixed tissues and animals;
- Molecular cloning and genome editing using the CRISPR technology;
- classical and non-classical model systems.
Qualifications: This position is open to all who have (1) low but healthy heart rates (less than 45 beats/min) or (2) zygotic twin siblings (i.e. identical twins).
Day-to-day supervisor for this project: Joseph Moreno, Staff Researcher
Hours: 12 or more hours
Biological & Health Sciences