The role of the gut microbiome in protection against M. tuberculosis
Ashley Wolf, Professor
Public Health
Applications for Spring 2024 are closed for this project.
The composition of the gut microbiome is thought to influence host susceptibility or protection against infectious diseases. Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis disease (TB), is the leading cause of death by an infectious agent worldwide. The literature suggests that Mtb can cause perturbations in the gut microbiota leading to dysbiosis, however the reverse is underexplored. We are interested in identifying key components of the gut microbiota in host susceptibility to Mtb using a mouse model.
Role: Your tasks will be to extract genomic DNA from mouse and human stool samples, do library preps for next-generation sequencing, and help in mouse husbandry.
Qualifications: Coursework in biology and an interest in learning new techniques.
Day-to-day supervisor for this project: Carolina Agudelo, Graduate Student
Hours: 9-11 hrs
Related website: awolflab.com
Biological & Health Sciences