Mouse Models of Vascular Pathogenesis and Regeneration
Rong Wang, Professor
UC San Francisco
Applications for Spring 2025 are closed for this project.
The vasculature supplies all cells in the body. A dysfunctional vasculature causes myriad diseases, including stroke, arterial occlusive diseases, hemorrhages, and vascular anomalies. Our long-term goal is to understand vascular abnormalities and Regeneration and to treat vascular diseases. Our strategy is to understand genes crucial for angiogenesis (new vessel formation) in the normal and diseased states. We employ cutting-edge mouse genetics to delete or express genes in a temporally controllable fashion in vascular cells. Using cell lineage specific and temporarily regulatable mouse genetic approach to manipulating candidate gene expression to generate animals modeling vascular diseases.
Role: Learn and assist in mouse genetics, anatomy, breeding, biopsy, genotyping, dissection, inventory, disease progression, injection, treatment, and microsurgeries; as well as immunostaining, microscopies, imaging, data analysis, ppt preparation, literature search/summaries/citations. Opportunities to earn authorship in publications.
Qualifications: 1. A career goal in life science research
2. Highly responsible, motivated, dependable, accurate, meticulous, and punctual.
3. Are interested in staying with the lab for at least one year
4. Able to come to UCSF at least 2 days a week (hours to be negotiated)
5. Enthusiastic to work with mice as a model system
6. Have taken upper division science courses
7. Strong hands-on, organizational, and communication skills
8. Fast learner who invites feedback for improvements
9. Prior Research experiences and strong writing/editing skill are a plus
10. Genetic background or course work is a plus.
11. Students who aim to pursue a Ph.D degree are encouraged to apply.
Day-to-day supervisor for this project: Rong Wang and TBN
Hours: 12 or more hours
Off-Campus Research Site: UCSF Parnassus and Mission Bay
Related website: https://profiles.ucsf.edu/rong.wang