Tissue Clearing/Light Sheet 3D Imaging/Computational analysis for Vascular Pathogenesis and Regeneration in Mouse Models
Rong Wang, Professor
UC San Francisco
Applications for Spring 2025 are closed for this project.
The vasculature supplies all cells in the body. A dysfunctional vasculature causes myriad diseases, including stroke, arterial occlusive diseases, hemorrhages, and vascular anomalies. Our long-term goal is to understand vessel Pathogenesis and Regeneration and to treat vascular diseases. Our strategy is to understand genes crucial for angiogenesis (new vessel formation) in the normal and diseased states. We employ cutting-edge mouse genetics to delete or express genes in a temporally controllable fashion in vascular cells. We combine these molecular approaches with mouse models of diseases and Tissue Clearing/Light Sheet 3D Imaging/ Computational analysis to uncover both the molecular signaling and mechanisms in normal development and disease progression/regression.
Qualifications: Role:
Learn and assist in mouse organ dissection, tissue clearing, and Light Sheet 3D Imaging, data acquisition, computational data analysis, ppt preparation, literature search/summaries/citations. Opportunities to earn authorship in publications.
Qualifications:
1. A research career goal in life science
2. A major in Biology and minor/background in Data Science.
3. Highly responsible, motivated, dependable, accurate, meticulous and punctual.
4. Are interested in staying with the lab for at least one year or longer
5. Able to come to UCSF at least 2 days a week (hours to be negotiated)
6. Python ability/skill/familiarity
7. Willing to work with mice or collaborate with mouse scientists
8. Have taken upper division science courses
9. Strong hands-on, organizational, and communication skills
10. Fast learner who invites feedback for improvements
11. Prior Research experiences and strong writing/editing skill are a plus
12. Students who aim to pursue a Ph.D degree are encouraged to apply.
Day-to-day supervisor for this project: Professor Rong Wang and TBN
Hours: 12 or more hours
Off-Campus Research Site: UCSF
Related website: https://profiles.ucsf.edu/rong.wanghttp://
Biological & Health Sciences