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Babak Javid - Professor, Medicine/Experimentsl Medicine
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
We have shown (in unpublished data) that antibodies specific for Mycobacterium tuberculosis (Mtb), complexed to live Mtb, can stimulate NLRP3 inflammasomes -- a multi-protein complex that is involved in pro-inflammatory signaling. However, the precise molecular mechanisms are not known. In this URAP project, the student will use latex-beads...
Biological & Health SciencesBabak Javid - Professor, Medicine/Experimentsl Medicine
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
Almost everything known about bacterial protein synthesis is from the study of "canonical" mRNAs in E. coli and other model organisms. However, many bacteria translate non-canonical mRNAs. A quarter of mRNAs in mycobacteria lack 5' UTRs -- but the "rules" governing leaderless translation are not fully understood. This project will...
Biological & Health Sciences