URAP

Steven Brenner - Professor, Plant and Microbial Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

RNA-seq has been widely used in biological and medical research because of its capability to quantify transcriptome changes. Researchers usually use their impressions and experience to choose whether to analyze transcriptome changes in gene expression or alternative splicing levels. A more systematic way to determine whether to focus on...

Steven Brenner - Professor, Plant and Microbial Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

Genome sequencing identifies a vast number of genetic variants. Predicting these variants’ molecular and clinical effects is one of the preeminent challenges in genetics. Accurate prediction of the impact of genetic variants improves our understanding of how genetic information yields molecular and cellular functions and is an essential step toward...

Steven Brenner - Professor, Plant and Microbial Biology

Status: Current Term Now Closed     Weekly Hours: 9-11 hrs     Location: On Campus

Proteins often fold into compact structural units, called domains. Protein domains are basic units of protein function and evolution. Delineating domain boundaries is a prerequisite for further analyses of protein structures. However, this process is largely a manual process and the accuracy of these computer programs is still not satisfactory...

Steven Brenner - Professor, Plant and Microbial Biology

Status: Full- no new appr needed     Weekly Hours: 12 or more hours     Location: On Campus

The field of genome interpretation is essential for our understanding of human biology and the advancement of personalized medicine. However, the rapid accumulation of genomic data far exceeds our capacity for reliable interpretation. Consequently, the majority of variation discovered by next generation sequencing technologies is of unknown significance. These variants...