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Eva Nogales - Professor, Molecular and Cell Biology
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
Retrons are bacterial immune systems that help protect cells from viral infection. Many retrons remain poorly characterized, particularly those found in clinically important bacteria. This project will investigate a newly identified retron system from an ESKAPE pathogen using biochemical and structural approaches. The long-term goal is to understand how...
Biological & Health SciencesEva Nogales - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Kinesin motors drive microtubule based intracellular transport, and autoinhibition is an intrinsic regulatory mechanism that ensures this transport is activated according to cellular needs. Aberrant activation of kinesins has been linked to neurodegenerative diseases (e.g., KIF1A-Associated Neurological Disorder), affecting neuronal morphology and neurotransmitter release. However, the molecular mechanisms underlying...
Biological & Health SciencesEva Nogales - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Glial cells (astrocytes, oligodendrocytes, and microglia), which make up half the brain volume, play essential roles in maintaining and protecting neurons. They regulate synaptic neurotransmission, insulate the neuronal axons, maintain their extracellular environment and are involved in immune defense, thereby playing a central role in the regulation of brain function...
Biological & Health Sciences