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Project Descriptions
Spring 2025

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Showing 4 projects out of 4 found. On page 1 out of 1.
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Data science project development in Alzheimer's disease (Agile)

Lea Grinberg - Professor, UC San Francisco

Status: Check back for status     Weekly Hours: to be negotiated     Location: Off Campus

Are you from Computer Science and want to know how to program in an agile project? Ok, this position is for you! We must have all our sample inventory organized… but it is time to be modern! We need a web application to do that! Do we know exactly how...

 Biological & Health Sciences

Unveiling the histological and molecular basis of sleep disturbances in neurodegenerative diseases

Lea Grinberg - Professor, UC San Francisco

Status: Check back for status     Weekly Hours: 9-11 hrs     Location: Off Campus

Background: Sleep disturbance is common among patients with neurodegenerative diseases. For instance, patients with Alzheimer’s disease (AD) experience excessive daytime sleepiness and sundowning. Progressive supranuclear palsy (PSP) features hyperarousal and decreased homeostatic sleep drive. Sleep disturbance generally precedes disease-defining symptoms, often by decades, suggesting that dysregulation of sleep is...

 Biological & Health Sciences

Optimizing and automating a cell counting image-processing pipeline for histological comparisons in Alzheimer’s Disease

Lea Grinberg - Professor, UC San Francisco

Status: Check back for status     Weekly Hours: 9-11 hrs     Location: Off Campus

The importance of histology to neuropathological research cannot be overstated. As a neurology lab, the histological characterization of proteopathies (including tauopathies, Aβ-amyloidosis, synucleiopathies, etc.) is core to our operations. From determining severity/progression of the pathology to identifying areas of selective vulnerability, immunohistochemistry and microscopy are critical tools for...

 Biological & Health Sciences

Diagnosing and monitoring prodromal Alzheimer’s Disease using novel locus ceruleus-based imaging volumetry

Lea Grinberg - Professor, UC San Francisco

Status: Check back for status     Weekly Hours: 9-11 hrs     Location: Off Campus

Despite intensive research on AD, effective disease-modifying treatments remain elusive, and novel tools for non-invasively assessing early brains lesions are needed. Our lab confirmed that the brain structures that consistently exhibit the earliest neuropathologic changes in AD, including neuronal loss, are not classically AD-associated cortical regions, but...

 Biological & Health Sciences

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