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Hernan Garcia - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Ultimately, in the developing embryo, cells make decisions individually based on local context. Individual cells don’t have access to the morphogen concentrations across the entire embryo. They can only be affected by the concentration of proteins in neighboring nuclei, and their individual response to signaling is crucial for developmental decision...
Biological & Health Sciences Mathematical and Physical SciencesHernan Garcia - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Gene expression is noisy. How much of this noise is due to variations in the environment of a gene locus, and how much is due to intrinsic limitations of the transcriptional machinery? This project aims to explore these questions by measuring the transcriptional dynamics of two identical, spatially coupled reporter...
Biological & Health Sciences Mathematical and Physical SciencesHernan Garcia - Professor, Molecular and Cell Biology
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: On Campus
A stochastic oscillator undergoes rhythmic motion but is governed by random fluctuations. One such example from the natural world is an oscillatory gene regulatory network known as the segmentation clock, which coordinates the formation of somites in vertebrates. Recent advances in our lab have allowed us to measure real-time...
Biological & Health Sciences Mathematical and Physical Sciences