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Trevor Fidler - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
We’re interested in identifying pathways which regulate how macrophage behave in atherosclerosis. In inflammatory sites like atheromas, macrophages accumulate. Recent single cell RNA sequencing has revealed that within these tissue macrophages can adopt multiple transcriptional states which can promote or suppress disease. We are currently utilizing CRISPR screening in vivo...
Trevor Fidler - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
We’re interested in understanding why clonal hematopoiesis is associated with cardiovascular disease. Clonal hematopoiesis is a high prevalent disease in the elderly which occurs when hematopoietic stem cells acquire cancer mutations that promote cell survival. People with clonal hematopoiesis have a 40% increase in mortality. However rather surprisingly this increase...