Binh Diep, Professor

Closed (1) Novel Immunotherapies for Treatment of Invasive Bacterial Infections

Applications for fall 2021 are now closed for this project.

The Diep lab at UCSF invites highly motivated undergraduate students to apply for two research positions. The goal of our research is to develop novel immunotherapies and vaccine against Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia.

Most of our URAP students have made significant contributions to their research projects and were recognized as coauthors in major publications. See below for selected publications coauthored by our undergraduate students (marked with *)

Nguyen NTQ, Gras E, Tran ND, Nguyen NNY, Lam HH*, Weiss WJ, Doan TNM, Diep BA. Pseudomonas aeruginosa Ventilator-Associated Pneumonia Rabbit Model for Preclinical Drug Development. Antimicrob Agents Chemother. 2021 May 10. PMID: 33972247.

Vu TTT, Nguyen NTQ, Tran VG, Gras E, Mao Y, Jung DH*, Tkaczyk C, Sellman BR, Diep BA. Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia. Antimicrob Agents Chemother. 2020 02 21; 64(3). PMID: 31844012.

Tran VG, Venkatasubramaniam A, Adhikari RP, Krishnan S, Wang X, Le VTM, Le HN*, Vu TTT, Schneider-Smith E*, Aman MJ, Diep BA. Efficacy of Active Immunization with Attenuated Alpha-Hemolysin and Panton-Valentine Leukocidin in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia. The Journal Of Infectious Diseases, 2020; 221:267-275.

Diep BA, Le VT, Badiou C, Le HN*, Pinheiro MG, Duong AH*, Wang X, Dip EC, Aguiar-Alves F, Basuino L, Marbach H, Mai TT*, Sarda MN, Kajikawa O, Matute-Bello G, Tkaczyk C, Rasigade JP, Sellman BR, Chambers HF, Lina G; IVIG-mediated protection against necrotizing pneumonia caused by MRSA. Science Translational Medicine, 2016; 8(357):357ra124.

The student will participate in rabbit-related studies to evaluate efficacy of novel immunotherapies for the treatment of pneumonia and septic shock in our state-of-the-art experimental ICU, which is fully equipped with mechanical ventilators, patient monitors, infusion pumps, cardiac ultrasound, and point-of-care blood analyzers.

Qualifications: No prior lab experience is required, although the student should have at least 3.5 GPA in science coursework at UCB. The students will receive training from and work with two cardiologists in the lab. During the academic year, the student will work 15-20 non-paid hours per week at University of California San Francisco/San Francisco General Hospital at 1001 Potrero Ave, San Francisco, CA 94110. There is no possibility for virtual work because all work will be done in our experimental ICU. The student is expected to work in the lab for at least two years, culminating in a senior honors thesis. If the student work exceeds expectation for three consecutive terms (Fall, Spring and Summer), then he/she may be hired into a paid work position.

Weekly Hours: 12 or more hours

Off-Campus Research Site: 1001 Potrero Ave, Blg 30, Rm3318
San Francisco, CA 94110

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