Binh Diep, Professor

Closed (1) Novel Immunotherapies for Treatment of Invasive Staphylococcal Infections

Applications for Spring 2019 are now closed for this project.

The Diep lab at UCSF invites highly motivated undergraduate students to apply for two research positions. The goal of our research is to develop novel immunotherapies and vaccine against Staphylococcus aureus, a leading cause of death by an infectious agent in the United States.

Most of our URAP students have made significant contributions to their research projects and were recognized as coauthors in major publications. See below for selected publications coauthored by our undergraduate students (bold face):

<b>This text is bold</b>

Diep BA, <b>Afasizheva A, Le HN</b>, Kajikawa O, Matute-Bello G, Tkaczyk C, Sellman B, Badiou C, Lina G, Chambers HF. Effects of Linezolid on Suppressing In Vivo Production of Staphylococcal Toxins and Improving Survival Outcomes in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia. Journal of Infectious Diseases 2013; 208:75-82.

Tattevin P, Schwartz BS, Graber CJ, Volinski J, <b>Bhukhen A, Bhukhen A, Mai TT, Vo NH, Dang DN, Phan TH</b>, Basuino L, Perdreau-Remington F, Chambers HF, Diep BA. Concurrent epidemics of skin and soft tissue infection and bloodstream infection due to community-associated methicillin-resistant Staphylococcus aureus. Clinical Infectious Diseases 2012; 55:781-8.

Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, <b>Mai TT</b>, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010; 107:5587-92.

Diep BA, Gill SR, <b>Chang RF, Phan TH, Chen JH, Davidson MG, Lin F, Lin J</b>, Carleton HA, Mongodin EF, Sensabaugh GF, Perdreau-Remington F. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet. 2006; 367:731-9.

The student will participate in animal-related studies to evaluate efficacy of novel immunotherapies for the treatment of prosthetic knee joint infection, aortic valve endocarditis, dermonecrosis, and necrotizing pneumonia.

Qualifications: During the academic year, the student will work 15-20 non-paid hours per week at University of California San Francisco/San Francisco General Hospital. The student may be able to continue over the summer in a paid position. No prior lab experience is required, although the student should have GPA > 3.5 in science coursework at UCB.

Weekly Hours: 12 or more hours

Off-Campus Research Site: 1001 Potrero Ave, Blg 30, Rm3318
San Francisco, CA 94110

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