URAP

Eva Raphael - Professor, UC San Francisco

Status: Check back for status     Weekly Hours: 6-8 hrs     Location: On Campus

Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, particularly among urban-dwelling women. UTIs are primarily caused by Escherichia coli (E. coli). UTIs may cause a range of complications from mild discomfort to severe kidney infections. As antibiotic resistance increases, treatment strategies for UTIs become ineffective...

Hilde Schjerven - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

The Schjerven Lab at UCSF studies the transcription factor Ikaros (encoded by the Ikzf1 gene) and its different biological roles in immune cell development and disease. In a recent collaborative work, we found that the transcription factor Ikaros is expressed in medullary thymic epithelial cells (mTEC), and important for the...

Hilde Schjerven - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

The Schjerven Lab at UCSF studies the transcription factor Ikaros (encoded by the Ikzf1 gene) and its different biological roles in immune cell development and disease. We have found that the transcription factor Ikaros is important in development of eosinophils, a type of white blood cell that is part of...

Hilde Schjerven - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

The Schjerven Lab at UCSF studies the transcription factor Ikaros (encoded by the Ikzf1 gene) and its different biological roles in immune cell development and disease. Ikaros is an important tumor suppressor in B-cell lineage acute lymphoblastic leukemia, and we have multiple projects in our lab to study how...

Youngho Seo - Professor, UC San Francisco

Status: Full- no new appr needed     Weekly Hours: 6-8 hrs     Location: Off Campus

Keywords: cancer, radiopharmaceutical therapy, targeted alpha therapy, alpha particles, image processing, dosimetry, machine learning, digital autoradiography Radiopharmaceutical therapy with alpha-particle emitters (⍺RPT) is an emerging cancer treatment method that has demonstrated high efficacy in clinical trials for several types of cancer. Improvement of these drugs requires thorough pre-clinical...

Youngho Seo - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 9-11 hrs     Location: Off Campus

Molecular imaging is a powerful method of interrogating biochemical properties of imaging subjects. Particularly in research, we use small animal positron emission tomography (PET) and single photon emission computed tomography (SPECT), which are combined with x-ray computed tomography (CT). More commonly, these imaging modalities are known as microPET/CT...

Youngho Seo - Professor, UC San Francisco

Status: Full- no new appr needed     Weekly Hours: 6-8 hrs     Location: Off Campus

Radiotherapy with alpha-emitting nuclides is an extremely promising technique in cancer therapy. The very short range of alpha particles compared to beta particles allows to deliver a much higher therapeutical dose to the lesion, sparing healthy tissue. A fundamental problem with this technique is the inability of current radiation...

Youngho Seo - Professor, UC San Francisco

Status: Full- no new appr needed     Weekly Hours: 6-8 hrs     Location: Off Campus

Keywords: deep learning, artificial intelligence, prediction, Alzheimer's disease, positron emission tomography, PET, image processing, FDG, glucose metabolism, amyloid Alzheimer's disease (AD) is the most common type of dementia, and a debilitating condition that affects a large number of aging populations. When symptoms occur, there are a very limited set of...

Steven Seyedin - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 6-8 hrs     Location: Off Campus

For patients with limited metastatic (stage IV) bladder cancer, high dose, high precision radiation therapy known as stereotactic body radiation therapy (SBRT), to all sites of disease can improve cancer outcomes and extend the time to needing additional therapy. However which patients truly benefit from SBRT is unclear. This study...

Jae Ho Sohn - Professor, UC San Francisco

Status: Full- no new appr needed     Weekly Hours: 6-8 hrs     Location: Off Campus

Radiologists are doctors who specialize in extracting clinically useful information from medical images (such as CT, chest X-ray, and MRIs) and communicating these findings with other doctors. We leverage abstract clinical reasoning and visual pattern recognition skills to extract hidden information in the images that may be important for...

Madhumita Sushil - Professor, UC San Francisco

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: Off Campus

LLMs have demonstrated tremendous potential in various domains, including healthcare. However, evaluating their outputs, especially in clinical settings, presents unique challenges. This project will compare the evaluation metrics obtained from automated methods for assessing free-text outputs generated by LLMs with the assessments from expert clinical judgment. The findings will...

Vasanth Vedantham - Professor, UC San Francisco

Status: Full- no new appr needed     Weekly Hours: 9-11 hrs     Location: Off Campus

The heart’s spontaneous rhythmicity has fascinated natural scientists from antiquity to the present. Particularly in the form of the palpable pulse, heart rhythm has always been among the most accessible physiological parameters to physicians, athletes and lay people, and yet the evolution, ontogenesis, and regulation of the heartbeat have remained...

Rong Wang - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: Off Campus

The vasculature supplies all cells in the body. A dysfunctional vasculature causes myriad diseases, including stroke, arterial occlusive diseases, hemorrhages, and vascular anomalies. Our long-term goal is to understand vascular abnormalities and Regeneration and to treat vascular diseases. Our strategy is to understand genes crucial for angiogenesis (new vessel...

Rong Wang - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: Off Campus

The vasculature supplies all cells in the body. A dysfunctional vasculature causes myriad diseases, including stroke, arterial occlusive diseases, hemorrhages, and vascular anomalies. Our long-term goal is to understand vessel Pathogenesis and Regeneration and to treat vascular diseases. Our strategy is to understand genes crucial for angiogenesis (new vessel...

Rong Wang - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: Off Campus

The vasculature supplies all cells in the body. A dysfunctional vasculature causes myriad diseases, including stroke, arterial occlusive diseases, hemorrhages, and vascular anomalies. Our long-term goal is to understand vessel Pathogenesis and Regeneration and to treat vascular diseases. Our strategy is to understand genes crucial for angiogenesis (new vessel...

Rong Wang - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: 12 or more hours     Location: Off Campus

The vasculature supplies all cells in the body. A dysfunctional vasculature causes myriad diseases, including stroke, arterial occlusive diseases, hemorrhages, and vascular anomalies. Our long-term goal is to understand vessel Pathogenesis and Regeneration and to treat vascular diseases. Our strategy is to understand genes crucial for angiogenesis (new vessel...

Peter Washington - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

This project involves building diagnostic machine learning models merging electronic health record (EHR) data with longitudinal Fitbit wearable data. After simply training these supervised learning models, the project will then focus on exploring explainable AI + algorithmic fairness issues with the dataset, all using Python-based machine learning. This project involves...

Wendy Yue - Professor, UC San Francisco

Status: Current Term Now Closed     Weekly Hours: to be negotiated     Location: Off Campus

Spiny mice are among the few mammals capable of shedding and regenerating large areas of skin, a unique adaptation that helps them escape predators. However, this ability comes with a challenge: how do they manage the pain from such severe injuries? This project aims to investigate potential mechanisms that allow...