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John Chorba - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated
A fundamental challenge in drug discovery is that any given therapeutic target requires its own customized strategy. The discovery of a recent compound that binds the human ribosome and inhibits translation in a sequence specific manner offers the potential to “drug” protein targets without the need for a traditional active...
Biological & Health SciencesJan Christoph - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: Off Campus
It is an exciting time in cardiovascular research: the combination of 3D imaging, deep learning, numerical modeling and high-performance computing opens doors to novel diagnostic capabilities. Our group develops computational and experimental methods for the imaging of the heart. We produce imaging data using fluorescence and 4D ultrasound imaging...
Engineering, Design & Technologies Biological & Health Sciences Mathematical and Physical SciencesJan Christoph - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
It is an exciting time in cardiovascular research: the combination of 3D imaging technology, deep learning, numerical modeling and high-performance computing opens doors to novel diagnostic capabilities. Our group develops computational and experimental methods for the imaging of the heart. We produce imaging data using fluorescence imaging and 4D...
Engineering, Design & Technologies Biological & Health Sciences Mathematical and Physical SciencesJan Christoph - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: Off Campus
It is an exciting time in cardiovascular research: the combination of 3D imaging technology, deep learning, numerical modeling and high-performance computing opens doors to novel diagnostic capabilities. Our group develops computational and experimental methods for the imaging of the heart. We produce imaging data using fluorescence imaging, catheter-based...
Engineering, Design & Technologies Biological & Health Sciences Mathematical and Physical SciencesSusana Chung - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: On Campus
This research project focuses on the understanding of how the visual system works in people with normal vision, as well as in people with uncorrectable sub-normal vision (visual impairment). Uncorrectable sub-normal vision can occur as a result of an eye disease (e.g. macular degeneration, the leading cause of...
Biological & Health Sciences Education, Cognition & PsychologySusana Chung - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: On Campus
This research project focuses on the understanding of how the visual system responds to the onset of vision loss as a result of eye diseases. By understanding how the visual system responds to vision loss, our ultimate goal is to develop effective rehabilitative strategies to help people with vision loss...
Biological & Health Sciences Education, Cognition & PsychologySusana Chung - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: On Campus
The research project focuses on the understanding of how the visual system recognizes faces and other objects in normally sighted people and people with low vision. Psychophysical methods, retinal imaging and functional brain imaging will be used to answer the research question...
Biological & Health Sciences Education, Cognition & PsychologySusana Chung - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: On Campus
Loss of vision in the central visual field brings about dramatic changes to everyday activities (e.g. reading, identifying objects). This research project focuses on identifying how the informative features of objects contribute to overall visual function, with the clinical goal of visual performance improvement by enhancing selected parts of objects...
Biological & Health Sciences Education, Cognition & PsychologyIain Clark - Professor, Bioengineering
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
This project aims to hack an Illumina HiSeqX to create an open-source sequencing platform for spatial analysis of single cells (RNA-seq, DNA-seq, etc on tissue). The HiSeqX contains advanced fluidics and optics made for Next Generation Sequencing (NGS). A community of hackers is working to repurpose these...
Engineering, Design & Technologies Biological & Health SciencesIain Clark - Professor, Bioengineering
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
You will assist a PhD student mentor in developing a technology to isolate cells based on DNA markers of HIV. This technique builds off of Clark et al.’s 2023 publication “HIV silencing and cell survival signatures in infected T cell reservoirs.” This project will involve microfluidics, flow cytometry, and...
Engineering, Design & Technologies Biological & Health SciencesIain Clark - Professor, Bioengineering
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
We recently developed a molecular method that categorizes the cellular connections and transcriptional profiles of glial cells in the mouse brain. The data from this technique can be represented as a highly connected network. The goal of this project is to discover ligand-receptor interactions that promote inflammation in the...
Engineering, Design & Technologies Biological & Health SciencesIain Clark - Professor, Bioengineering
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
We recently developed a molecular method that categorizes the cellular connections and transcriptional profiles of glial cells in the mouse brain. The data from this technique can be represented as a highly connected network. The goal of this project is to discover ligand-receptor interactions that promote inflammation in the...
Engineering, Design & Technologies Biological & Health SciencesChris Conroy - Staff Curator, Museum of Vertebrate Zoology
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: Off Campus
The California vole is a common species of rodent in California, with some interesting complexity. There are two distinct groups within the species that come into contact in Southern California. We have been studying this contact zone from various morphological, climatic and genetic perspectives. The species is also found in...
Biological & Health SciencesChris Conroy - Staff Curator, Museum of Vertebrate Zoology
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: On Campus
The Trowbridge shrew, Sorex trowbridgii, is a common small mammal across middle to northern California, extending into Oregon and Washington. Deep genetic divergence within the species suggests incipient speciation is underway. This project has two current goals. 1) Develop more, and novel molecular data to investigate depth of divergence and...
Biological & Health SciencesLaurent Coscoy - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Human cytomegalovirus (HCMV) is a herpesvirus that infects 60% of adults in developed countries and more than 90% in developing countries. Usually, it is controlled by a vigorous immune response so infections are usually asymptomatic or symptoms are mild. However, if the immune system is compromised (for example in people...
Biological & Health SciencesYang Dan - Professor, Molecular and Cell Biology
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
Sleep problems are a common symptom of Parkinson’s disease (PD) and in some cases an early warning sign before movement deficits. Sleep problems in PD are diverse and can be made worse by medications that treat other PD symptoms by affecting dopamine or norepinephrine levels in the brain. While dopamine...
Biological & Health SciencesTodd Dawson - Professor, Integrative Biology
Status: Full- no new appr needed Weekly Hours: 6-8 hrs Location: On Campus
California’s coastal grasslands, hosting roughly 90% of the state’s rare and endangered life, and 40% of the state’s native vegetation, are an important carbon sink, and a valuable natural and cultural resource. Over the past 150 years, native grasslands have waned in an absence of herbivory and fire disturbance, which...
Biological & Health SciencesAbby Dernburg - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Human reproduction is highly asymmetric given that women have much more limited reproductive health spans than men. Women experience a sharp age-dependent decline in oocyte quality, which arises largely through errors in meiosis, the specialized cell division that reduces the genome by half. We study the fundamental mechanisms of...
Biological & Health SciencesAbby Dernburg - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Meiosis is a specialized cell division that produces gametes with half the genome content of somatic cells. During meiosis, the two copies of each chromosome inherited from the two parents must physically pair along their lengths through a process called synapsis, in which a protein complex called the synaptonemal complex...
Biological & Health SciencesRobert Dudley - Professor, Integrative Biology
Status: Full- no new appr needed Weekly Hours: 6-8 hrs Location: On Campus
Flying insects are the most diverse and abundant form of animal life in the terrestrial biosphere. However, the origins of insect flight remain obscure given the absence of a transitional fossil record. This project will involve construction of a small robot that mimics the likely morphology of early insects, and...
Biological & Health SciencesDiane Erwin - Senior Museum Scientist, Museum of Paleontology
Status: Full- no new appr needed Weekly Hours: 6-8 hrs Location: On Campus
This project is part of a NSF grant to digitize and photograph fossil ferns in the Museum of Paleontology as part of the Advancing the Digitization of Biological Collections (ADBC) Thematic Collections program. The specimen record data and images generated from the project will be uploaded to the UCMP online...
Biological & Health SciencesDiane Erwin - Senior Museum Scientist, Museum of Paleontology
Status: Full- no new appr needed Weekly Hours: 3-5 hrs Location: On Campus
The UCMP amber collection from Chiapas, Mexico is composed mostly of fossil insects. The project is funded in part by the Institute for Museum and Library Services (IMLS) to conserve this collection by embedding the amber pieces in epoxy resin and providing specimen images for presentation on the web for...
Biological & Health SciencesDan Feldman - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
This project aims to investigate the effects of body movements and arousal state on behavioral performance accuracy, and on neural activity in specific cell classes during goal-directed behavior in mice...
Biological & Health SciencesDan Feldman - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
This project uses a novel approach to investigate the effects of selective attention on behavioral performance accuracy and neural activity in specific cell classes during goal-directed behavior in mice...
Biological & Health SciencesDan Feldman - Professor, Molecular and Cell Biology
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
This neuroscience project will use immunohistochemistry to test for abnormalities in inhibitory interneurons in cerebral cortex in mouse models of autism. Interneuron hypofunction is common in mouse models of autism, but how this impairment in inhibition arises is unclear. We focus on two interneuron types, parvalbumin-positive interneurons (PV cells...
Biological & Health SciencesLia Fernald - Professor, Public Health
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: On Campus
Around one third of young children in Latin America co-reside with a grandparent. Unlike other regions, intergenerational cohabitation has remained common even with increasing economic prosperity. Grandparents may provide additional care for children with time or financial resources, yet they may also be a burden on parents if the...
Social Sciences Biological & Health SciencesLia Fernald - Professor, Public Health
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: Off Campus
Over 250 million children under five years in low- and middle-income countries (LMICs) have been estimated to be at risk of poor development, accounting for 43% of young children living in those countries (Lu et al., 2016). There are many reasons that children are at risk for poor development...
Social Sciences Biological & Health SciencesLia Fernald - Professor, Public Health
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: On Campus
In Kenya, over 70% of the population is at risk of malaria, with the areas around Lake Victoria and on the coast presenting the highest risk, and children under age 5 and pregnant women being most vulnerable to infection. Over half of malaria patients access treatment via pharmacies, which are...
Social Sciences Biological & Health SciencesLia Fernald - Professor, Public Health
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: On Campus
Background: Every seven minutes a woman is a victim of domestic violence in Brazil. Research on intimate partner violence shows that victimization is not an isolated incident. Because of the repetition of abuse, it’s possible that some women seek assistance from multiple sectors over the course of their victimization. Other...
Social Sciences Biological & Health SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
Many painful pathologies of the spine involve the first sacral (S1) vertebra. For example, damage to the endplates of S1 (in particular, the region near the lumbar intervertebral disc) can cause painful lesions in the vertebral bone marrow—such lesions are relatively common in patients with chronic low back pain...
Biological & Health SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
Advances in magnetic resonance imaging (MRI) technology enable novel, quantitative, and non-invasive estimation of the biochemical composition of musculoskeletal tissues. The new ability to non-invasively assay tissue composition using MRI has major implications for understanding spinal pathologies related to low back pain, such as intervertebral disc degeneration. Recent...
Biological & Health SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The Orthopaedic Biomechanics and Biotransport Laboratory at UCSF conducts research related to structure-function relationships in musculoskeletal tissues, with a particular focus on the mechanisms of nutrient transport in bone and cartilage and harnessing nutrient transport for tissue repair and regeneration. The lab combines engineering and biology approaches for (1...
Biological & Health SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The Orthopaedic Biomechanics and Biotransport Laboratory at UCSF conducts research related to structure-function relationships in musculoskeletal tissues, with a particular focus on the mechanisms of nutrient transport in bone and cartilage and harnessing nutrient transport for tissue repair and regeneration. The lab combines engineering and biology approaches for (1...
Biological & Health SciencesSeth Finnegan - Professor, Integrative Biology
Status: Current Term Now Closed Weekly Hours: to be negotiated Location: On Campus
For tens of millions of years large parts of California’s Central Valley were flooded by the ocean, creating an inland sea with a unique ecosystem including now-extinct species of clams, snails, sand dollars, corals, and other groups familiar from modern California beaches. Some of the species that lived in...
Biological & Health SciencesSeth Finnegan - Professor, Integrative Biology
Status: Current Term Now Closed Weekly Hours: to be negotiated Location: On Campus
Besides coral, marine reefs are made up of many other strange invertebrates, including the little-known “moss animal”, or bryozoan. These abundant, microscopic filter-feeders grow in colonies and build elaborate domes, lacework, and tree-like structures on the ocean floor, from the intertidal to the abyss, from the poles...
Biological & Health SciencesSeth Finnegan - Professor, Integrative Biology
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: On Campus
The rise of the Isthmus of Panama ~3 million years ago was arguably the most important biotic and oceanographic event of the past 60 million years. By connecting North and South America, the rise of the Isthmus caused the Great American interchange of terrestrial plant and animal species. In the...
Biological & Health SciencesSeth Finnegan - Professor, Integrative Biology
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: On Campus
Mass extinctions in the fossil record provide us with case studies of biodiversity crises and global change that extend beyond human timescales. Approximately 445 million years ago, about 80% of marine animal species on Earth became extinct during a period of global climate change; however, the primary drivers and the...
Biological & Health SciencesJohn Flanagan - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
We are focused on elucidating the role and molecular mechanisms of protective lipid mediators that are essential for regulating and orchestrating routine and healthy immune responses and neuroprotection. Research in our lab uses in vitro and mouse models and bioinformatics to discover and define protective pathways and therapeutic targets in...
Biological & Health SciencesJohn Flanagan - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: On Campus
This project is centered around RNA sequencing and differential expression analysis in the context of glaucoma research. Specifically, the project aims to compare the gene expression profiles in cell culture and mice models to identify target genes implicated in glaucoma pathogenesis...
Biological & Health SciencesJohn Flanagan - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
This project employs immunohistochemistry techniques to delve into glial cell intricacies in glaucoma, followed by a detailed morphometric analysis using Imaris software. By combining these advanced methodologies, we aim to uncover subtle cellular variations associated with glaucoma pathogenesis...
Biological & Health SciencesSuzanne Fleiszig - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: On Campus
Pseudomonas aeruginosa is the most common cause of contact lens-mediated microbial keratitis. Our lab uses in-vitro and in-vivo models to study the adaptation of Pseudomonas aeruginosa to the intracellular environment. Our recently published paper shows that intracellular bacteria persist in vacuoles, where they resist high-dose antibiotic...
Biological & Health SciencesSuzanne Fleiszig - Professor, Optometry
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: On Campus
Pseudomonas aeruginosa is found to be the main causative agent of infection of human corneal and bronchial epithelial cells in bacterial keratitis and bacterial pneumonia respectively. To understand the etiology of chronic bacterial infection we look to determine the steps associated with intracellular biofilm formation by Pseudomonas aeruginosa. We aim...
Biological & Health SciencesSuzanne Fleiszig - Professor, Optometry
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Our lab has shown that P. aeruginosa can interact with and invade epithelial cells to establish an intracellular niche. We have recently found that intracellular bacteria occupy a subcellular compartment where they resist high dose antibiotic treatment. We are interested in understanding the factors associated with bacterial persistence and enhanced...
Biological & Health SciencesSuzanne Fleiszig - Professor, Optometry
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: On Campus
Contact lens wearers suffer a multitude of complications due to extended contact lens wear, including para-inflammation and bacterial infection. Contact lens wear alters the resident immune cells in the cornea specifically neutrophils after 6 days of continuous contact lens wear and this phenomenon has been observed in mice cornea...
Biological & Health SciencesBrent Fulton - Associate Director, Public Health
Status: Full- no new appr needed Weekly Hours: 6-8 hrs Location: On Campus
The Antitrust Division of the U.S. Department of Justice, the Federal Trade Commission, and state offices of the attorney general are responsible to promote and protect competition; however, their resources to scrutinize proposed mergers and acquisitions are limited. The purpose of this project is to do background research for utilizing...
Biological & Health Sciences Social SciencesBrent Fulton - Associate Director, Public Health
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: On Campus
Healthcare providers and insurers have consolidated in the past decade, leading to higher prices without a commensurate increase in quality. The study will extend the evidence base on the effects of healthcare consolidation, including understanding the impacts of hospital-to-hospital affiliations and the impacts of private equity firms acquiring...
Biological & Health Sciences Social SciencesBrent Fulton - Associate Director, Public Health
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: On Campus
In the United States, government spending on programs (excluding health programs) targeting low-income populations total about $450 billion per year, whereas personal savings in the U.S. totals about $1 trillion per year (but reached $2 to $3 trillion in 2020 and 2021 because of Covid/recession fears, which are...
Biological & Health Sciences Social SciencesBrent Fulton - Associate Director, Public Health
Status: Full- no new appr needed Weekly Hours: 6-8 hrs Location: On Campus
AI technology and AI tools will change the healthcare landscape. The purpose of this project is two-fold. First, the project aims to understand AI technology's impact on the broader economy coupled with a focus on healthcare, including diagnostics, treatments, drug development and workflow processes. Second, the project...
Biological & Health Sciences Social SciencesRosemary Gillespie - Professor, Environmental Science, Policy and Management
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: On Campus
This project looks at how communities of organisms come together, and the role of ecology (migrating into a community, trophic level) and evolution (adaptation and speciation) in determining the composition of species in a community. This in turn will provide information on sensitivity to invasion and probability of speciation and...
Biological & Health Sciences Environmental IssuesRosemary Gillespie - Professor, Environmental Science, Policy and Management
Status: Full- no new appr needed Weekly Hours: 6-8 hrs Location: On Campus
No matter the size, all organisms interact with the world via their senses. Sensory input dictates reactions to stimuli, and the ability of organisms to adapt their neurological and sensory structures is critical to success and survival. Web building spiders in particular use webs as an extension and enhancement of...
Biological & Health Sciences Environmental Issues